Repeated exposure to formaldehyde can possibly lead to cancer. Vaccine 2013;31:2738-2743. Skin Contact. Formaldehyde is I… Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures. 3 Exposure may cause wheezing, asthma attacks and other respiratory symptoms. It is extremely irritating to the mucous membranes and is associated with certain types of cancer in humans and other animals. Human and animal studies indicate that formaldehyde, at certain exposure levels, can be irritating to the upper respiratory tract and eyes with inhalation exposure, to the skin with dermal exposure, and to the gastrointestinal tract with oral exposure. While formaldehyde is a likely cause of nasopharyngeal cancer, the quantities contained in vaccines are not sufficient to cause cancer. Overview; Side Effects; Professional; More; Uses of Formaldehyde: It is used to get rid of warts. We investigated the effects of inhaled formaldehyde on anxiety, depression, cognitive capacity and central levels of glucocorticoid receptor and tyrosine hydroxylase in mice. Havrix: ≤ 0.05 mg (pediatric), ≤ 0.1 mg (adult), Vaqta: 0.0004 mg (pediatric), 0.0008 mg (adult), Menactra®  quantity per dose: < 0.00266 mg, ©2020 The Children’s Hospital of Philadelphia. Formaldehyde irritates the nose, eyes, and throat. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Some examples of workers at risk of being exposed to formaldehyde include the following: NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. The minimal concentration of formaldehyde that can be detected by odor is similar to the level that produces minimal irritant effects on the eyes and in the pulmonary airway, thereby serving as a warning of exposure to the compound. The Vaccine Education Center staff regularly reviews materials for accuracy. These irritations can happen at low levels of formaldehyde, especially in people who are especially sensitive to the odors. The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. It’s used in glues and resins, dyes, textiles, disinfectants, building materials, automobile parts, embalming, and laboratories. 1,2 Other short-term effects include headache, runny nose, nausea and difficulty breathing. The level of exposure depends upon the dose, duration, and work being done. Subsequent exposure may cause severeallergic reactions of the skin, eyes and respiratorytract. Those with asthma may have exacerbation of symptoms when exposed to formaldehyde. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. What Happens When the Immune System Does Not Work Properly? If you work in an industry that uses formaldehyde, please read chemical labels and the accompanying Safety Data Sheet for hazard information. Philadelphia, PA 19104, Pharmacokinetic modeling as an approach to assessing the safety of residual formaldehyde in infant vaccines, Diphtheria, Tetanus and Pertussis Vaccines, Haemophilus influenzae type B (Hib) Vaccine, Japanese Encephalitis Virus (JEV) Vaccine, Vaccine- and Vaccine Safety-Related Q&A Sheets, “Special Topics” Online Series Q&A Sheets, Antibody-dependent enhancement (ADE) and vaccines, Autoimmune/Inflammatory Syndrome Induced by Adjuvants, Vaccine Considerations for Specific Groups, Vaccine Considerations for New and Expectant Moms, Evaluating Scientific Information and Studies, Licensure, Recommendations and Requirements. The general use made of formaldehyde—especially in the form of the commercial 40 per cent. Find patient medical information for Formaldehyde on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. Centers for Disease Control and Prevention. Formaldehyde. Formaldehyde has been found in at least 29 of the 1,669 National Priorities List sites identified by the Environmental Protection Agency (EPA). You should not use it to replace any relationship with a physician or other qualified healthcare professional. in forest fires, automobile exhaust, and tobacco smoke. Although formaldehyde is diluted during the manufacturing process, residual quantities of formaldehyde may be found in several current vaccines (see table below). Pharmacokinetic modeling as an approach to assessing the safety of residual formaldehyde in infant vaccines. Following a single intramuscular dose of 200 micrograms of formaldehyde, which is equivalent to the amount of formaldehyde received from DTaP, Hib, IPV, and hepatitis B at a single office visit, formaldehyde was completely removed from the site of injection within 30 minutes. It is also used as a food preservative and in household products, such as antiseptics, medicines, and cosmetics. Preservatives used in some medicines and cosmetics may contain formaldehyde. Applies to formaldehyde topical: external solution. Formaldehyde (and closely related formalin and glutaraldehyde) is an organic chemical usually used in a water solution as a preservative and disinfectant. 88): Formaldehyde, IARC Monograph (Vol. Why should I be concerned about exposure to formaldehyde? Learn more from the Agency for Toxic Substances and Disease Registry about the health effects of formaldehyde exposure. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Materials in this section are updated as new information and vaccines become available. Formaldehyde is known to cause cancer Working with formaldehyde may increase your chances of having fertility problems or a miscarriage 62): Wood Dust and Formaldehyde, United Nations Environmental Programme (OECD SIDS): Formaldehyde, National Institute for Occupational Safety and Health, U.S. Department of Health & Human Services, Agricultural workers who work in confinement livestock production, Construction workers who work with resin manufactured products, Workers who manufacture plastics, resins and foam insulation, Beauticians who apply dyes and smoothing products. High levels of exposure may cause some types of cancers. ; It is used to treat odor and very bad sweating of the feet. When exposed to the compound for an appreciable length of time, the throat may feel raw and sore. Not all influenza vaccines contain formaldehyde, but some preparations contain amounts between < 0.005 – 0.1 mg. Mitkus RJ, Hess MA, Schwartz SL. When produced in the atmosphere by the action of sunlight and oxygen on atmospheric methane and other hydrocarbons, it becomes part of smog. solution in water, known as formalin—as a disinfectant, as an embalming fluid by undertakers, and in histologic laboratories makes the experimental study of its toxic effects desirable. PRECAUTIONS: Before using formaldehyde, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. It has also been associated with decreased fertility and adverse reproductive effects. And if you don't drop dead from respiratory failure or fall into a coma, drinking even tiny doses of concentrated formaldehyde can bring convulsions, stomach pain, diarrhea, vomiting, vertigo and a host of other very bad side effects [source: U.S. National Library of Medicine]. There are limited data available on the direct effects of exposure to formaldehyde during pregnancy. Formaldehyde is an environmental pollutant that is also generated in substantial amounts in the human body during normal metabolism. CDC twenty four seven. Workers may be harmed by exposure to formaldehyde. Concerns about safety have focused on formaldehyde in part because high concentrations of formaldehyde can damage DNA (the building block of genes) and cause cancerous changes in cells in the laboratory. Formulations. In significant doses, the chemical is a neurotoxin. What are some side effects that I need to call my doctor about right away? The irritant effects are reversible when exposure is discontinued. Among the acute effects of formaldehyde are irritations of the eyes, the nose, and the throat. Formaldehyde, a major component in embalming fluid, is legal to purchase and possess and has become popular due to its euphoric properties. Last updated on Jul 21, 2020. Formaldehyde is toxic over a range of doses; chances of exposure and subsequent harmful effects are increased as (room) temperature increases, because of FA's volatility. Assuming an average weight of a 2-month-old of 5 kg and an average blood volume of 85 ml per kg, the total quantity of formaldehyde found in an infant's circulation would be about 1.1 mg, a value about 1,500 times more than the amount an infant would be exposed to in any individual vaccine. A medical review notes it’s been linked to a higher risk of cancers of the nose and the blood cancer leukemia. The bronchoconstrictive effects of formaldehyde exposure may be partially responsible for the lower airway discom fort reported in the study upon which the 8-hour and chronic RELs are based. Formaldehyde is essential in human metabolism and is required for the synthesis of DNA and amino acids (the building blocks of protein). Most formaldehyde produced in the United States is for the manufacture of resins, such as urea-formaldehyde, used to make the adhesives for pressed wood products, such as particleboard, furniture, paneling, cabinets, and other products. It is commonly used in producing household products, such as adhesives, coatings, dishwashing liquids, fabric softener, glues and paper products. This aldehyde is a well‐established neurotoxin that affects memory, learning, and behavior. Pure formaldehyde is a colourless, flammable gas with a strong pungent odour. Other sources include tobacco smoke and car emissions. Acute exposure is highly irritating to the eyes, nose, andthroat and can make anyone exposed cough andwheeze. Formaldehyde exposure to the skin can cause irritation and may burn the skin. At the same time, the eyes may begin to feel as if there is something grainy resting against each eyeball. Formaldehyde is classified as a human carcinogen (cancer-causing substance). Therefore, all humans have detectable quantities of natural formaldehyde in their circulation (about 2.5 ug of formaldehyde per ml of blood). (Formaldehyde is a natural product of single-carbon metabolism.) 74-126 (1976), NIOSH Skin Notation Profiles: Formaldehyde/Formalin, Agency for Toxic Substances Disease Registry (ATSDR)–ToxFAQs: Formaldehyde, ATSDR’s Medical Management Guidelines (MMGs): Formaldehyde, ATSDR Toxicological Profile for Fomaldehyde, Environmental Protection Agency (EPA)–Chemistry Dashboard: Formaldehyde, EPA Acute Exposure Guideline Levels (AEGLs): Formaldehyde, EPA Health Effects Notebook for Hazardous Air Pollutants: Formaldehyde, EPA Sources of Indoor Air Pollution: Formaldehyde, Occupational Safety and Health Agency (OSHA) Chemical Sampling Information: Formaldehyde, OSHA Safety and Health Topics: Formaldehyde, OSHA Hazard Alert: Hair Smoothing Products That Could Release Formaldehyde, National Library of Medicine (NLM)–Haz Map: Formaldehyde, NLM (Household Products Database): Formaldehyde, National Toxicology Program (NTP) Report on Carcinogens (Fourteenth Edition): Formaldehyde, New Jersey Hazardous Substance Fact Sheets: Formaldehyde, Canadian Centre for Occupational Health and Safety (CCOHS): Formaldehyde, European Chemical Agency(ECHA): Formaldehyde, INCHEM (Screening Information Data Set-SIDS): Formaldehyde, International Chemical Safety Cards: Formaldehyde, World Health Organization (WHO) Environmental Health Criteria 89: Formaldehyde, International Agency for Research on Cancer (IARC) Monograph (Vol. Other effects seen from exposure to high levels of formaldehyde in humans are coughing, wheezing, chest pains, and bronchitis. This finding raised the question of whether formaldehyde exposure could also cause cancer in humans. Health Effects of Formaldehyde Formaldehyde can cause irritation of the skin, eyes, nose, and throat. Health Effects Associated with Formaldehyde Exposure: Very low levels of formaldehyde, as seen with off-gassing from certain building materials or new furnishings made with pressed wood, can irritate and burn the eyes, nose, throat, and skin. Formaldehyde is used in many industries. Concerns about safety have focused on formaldehyde in part because high concentrations of formaldehyde can damage DNA (the building block of genes) and cause cancerous changes in … It is used in the production of fertilizer, paper, plywood, and some resins. The authors concluded that formaldehyde in vaccines continues is safe. In 1980, laboratory studies showed that exposure to formaldehyde could cause nasal cancer in rats. 4 The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards. Quantities of formaldehyde at least 600 times greater than the amount contained in vaccines have been fed safely to animals in drinking water. Formaldehyde is a colorless, flammable, strong-smelling chemical widely used to make home building products. Many studies have been conducted to evaluate the effects of FA during systemic and respiratory exposures in rats. National Institute for Occupational Safety and Health (NIOSH), (May 1994). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Generic Name: Formaldehyde (for MAL de hyde) Brand Name: Formadon, Lazerformalyde Medically reviewed by Drugs.com. Formaldehyde exposure may cause eye irritation. Effects on the unborn child are more likely to occur if the exposure to formaldehyde causes the mother to become unwell. According to the Occupational Health and Safety Agency for Healthcare in British Colombia, long-term exposure to formaldehyde can result in skin sensitization and is associated with an increased risk of cancer 1 3. Formaldehyde (CH₂O) is a colorless, highly toxic, and flammable gas at room temperature. However, formaldehyde is easy to find in our daily life. Although the short-term health effects of formaldehyde exposure are well known, less is known about its potential long-term health effects. Therefore, is not possible to draw any definitive conclusions. It is used in the production of fertilizer, paper, plywood, and some resins. You will be subject to the destination website's privacy policy when you follow the link. The average quantity of formaldehyde to which a young infant could be exposed to in the first two years of life may be as high as 0.7 – 0.8 mg (see table below). This quantity of formaldehyde is considered to be safe for two reasons: Quantity per dose: ≤ 0.005 mg – 0.1 mg, Quantity per dose: ≤ 0.005 mg – ≤ 0.1 mg, Quantity per dose: < 0.0075 mg (pediatric); < 0.015 mg (adult and dialysis formulations). For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. Most of us probably dont feel familiar with the name of this particular substance. OSHA Fact Sheet, (April 2011). Search the HHE database for more information on chemical topics. The following references aid in recognizing formaldehyde hazards in the workplace. It is also a cancer hazard. When formaldehyde is present in the air at levels higher than 0.1 parts per million (ppm), some people may have health effects, such as: watery eyes burning sensations of the eyes, nose, and throat Learn about formaldehyde, which can raise your risk of myeloid leukemia and rare cancers of or near the nasal cavity. It is also used as a food preservative and in household products, such as antiseptics, medicines, and cosmetics In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), Managing Chemical Safety in the Workplace, NIOSHTIC-2 search results on formaldehyde, Immediately Dangerous to Life or Health (IDLH) Value Profile: Formaldehyde, NIOSH Worker Health Study Summaries–Embalming Students (Formaldehyde Exposure), NIOSH Worker Health Study Summaries–Garment Workers, Criteria for a Recommended Standard: Occupational Exposure to Formaldehyde, DHHS (NIOSH) Publication No. Formaldehyde. The effects of inadvertent exposure are fairly well known, but the effects of intentional ingestion have only recently been investigated. 3401 Civic Center Blvd. Formaldehyde is an intermediate in the oxidation (or combustion) of methane, as well as of other carbon compounds, e.g. According to the United States Environmental Protection Agency (EPA), formaldehyde is a colorless, flammable, and strong-smelling chemical. Children’s Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. Formaldehyde exposure is toxic to the brains of mammals, but the mechanism remains unclear. Aside from ALS risk or other nervous system consequences, formaldehyde is a respiratory irritant that causes chest pain, shortness of breath, … Useful search terms for formaldehyde include “methanal,” “methyl aldehyde,” “methylene oxide.”. Formaldehyde. Formaldehyde can cause irritation of the eyes, nose, and throat and neurological effects. Prolonged exposure to formaldehyde has been associated with cancers of the lung, nasopharynx, orpharynx and nasal passages (nose and throat) and some studies suggest formaldehyde may cause leukemia, particularly myeloid leukemia, in humans. The authors estimated the levels of formaldehyde in blood and total body water following exposure to formaldehyde-containing vaccines and compared them with endogenous background levels. You may report side effects to Health Canada at 1-866-234-2345. Formaldehyde is released by numerous agents, such as paraformaldehyde, dichlorophene, Dowicil 75 and Dowicil 200 (cis-1-(3-chloroalkyl)-3,5,7-triaza-l-azonia-adamantane chloride), bronopol, Biocide DS 52–49 (1,2-benzoisothiazoline-3-one plus a formaldehyde releaser), and Bakzid (cyclic aminoacetal). Exposure to formaldehyde can irritate the skin, throat, lungs, and eyes. Provides information on the harmful effects of formaldehyde on workers and how employers can protect them. Formaldehyde may increase the risk of some cancers over time. The following resources provide information about occupational exposure to formaldehyde. Peak concentrations of formaldehyde in blood were estimated to be less than 1 percent of the level of formaldehyde naturally produced by the body. The Health Hazard Evaluation Program (HHE) conducts onsite investigations of possible worker exposure to chemicals. 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